Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp18 | Bone biomechanics and quality | ECTS2014

Influence of PTH treatment on the bone tissue mechanics of rats with type 2 diabetes mellitus using mechanical tests and finite element modelling

Campbell Graeme , Hamann Christine , Picke Ann-Kristin , Rauner Martina , Huber Gerd , Morlock Michael , Hofbauer Lorenz , Gluer Claus-Christian

Diabetes mellitus results in increased skeletal fragility through reduced bone mineral density and altered collagen structure. How these changes affect bone mechanics at the tissue level remains largely unclear. Anti-osteoporosis medications improve bone mass, but whether they can fully restore tissue strength in diabetic bone, where collagen quality is compromised, has not been fully elucidated. The objective of this study was to determine the effect of type 2 diabetes mellit...